The Pancreatic Cancer Action Network and the American Association for Cancer Research awarded 14 grants totaling more than $5 million today to scientists throughout the country to support their research in the field of pancreatic cancer, including three Massachusetts cancer researchers.
The Bay State grant recipients include:
- Costas Lyssiotis of Beth Israel Deaconess Medical Center will receive $600,000 to further evaluate the dependence of pancreatic cancer cells on the nutrients glucose and glutamine to develop innovative targeted therapies that selectively eliminate diseased cells.
- Dr. Andrew Aguirre of the Dana-Farber Cancer Institute will receive $45,000. Through a technology project called "Project Achilles," which seeks to discover the "Achilles heel" vulnerability of pancreatic cancer cells that have K-Ras mutation, Aguirre and colleagues hope to establish the translational potential of therapeutic gene silencing in human pancreatic cancer.
- Yves Boucher of Massachusetts General Hospital will receive $200,000. He proposes to attack desmoplasia, or growth of fibrous connective tissue that surrounds pancreatic tumors, by two approaches. Boucher will test whether a medicine designed to treat high blood pressure could open up some of the blood vessels around the tumor in a mouse model of pancreatic cancer. Also, a cell type known as macrophages may be able to chew up some of the desmoplastic tissue.
This year's total funding level represents the largest annual disbursement since the PCAN introduced the program in 2003, officials said. To date, the organization has awarded 94 research grants to researchers at institutions around the country totaling nearly $18 million.
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